One
of the X chromosomes is completely and permanently inactivated during a
female's early development in the womb. Research into mice has shown
that a ribonucleic acid (RNA) molecule called Xist plays a pivotal role
in the process. Several hundred copies of this molecule attach
themselves to one of the two X chromosomes, these RNA molecules dock
onto other molecules which then inactivate the chromosome. Spen gene is
very important for X chromosome inactivation.
Ref: Asun Monfort et al., 2015, Cell Reports.
DOI: 10.1016/j.celrep.2015.06.067
No comments:
Post a Comment